You will find there's launch of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to reduce afferent soreness transmission and deliver analgesia. For that reason, prescription drugs like clonidine that goal alpha-two receptors can impact the transmission of agony. Applies to clonidine: https://bookmarkvids.com/story21275217/the-best-side-of-onolidine