Epidural clonidine utilised being an adjunct to regional anesthetics has three unique mechanisms of motion. First, the stimulation of alpha-2-receptors while in the dorsal horn lowers pain transmission. Secondly, clonidine could potentially cause nearby vasoconstriction that limits vascular elimination of regional epidural anesthetics. Clonidine is distributed in breast milk; https://www.proleviate.com/post/the-new-pain-killer-conolidine